On a starry night, Jack and Jill separately meet a fortune teller who predicts they will meet the love of their life before the end of the year, which happens to be only five days away.

As middle schooler Emily Elizabeth struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend from a magical animal rescuer. When Clifford becomes a gigantic red dog in her New York City apartment and attracts the attention of a genetics company who wish to supersize animals, Emily and her clueless Uncle Casey have to fight the forces of greed as they go on the run across New York City and take a bite out of the Big Apple. Along the way,...